Sunday, 8 December 2013

NEPHRITIS


NEPHRITIS




DEFINITION


Nephritis is inflammation of the kidneys and may involve the glomeruli, tubules, or interstitial tissue surrounding the glomeruli and tubules. 



DEscription

The most prevalent form of acute nephritis are :

1)      Glomerulonephritis

Ø This condition affects children and teenagers far more often than it affects adults. It is inflammation of the glomeruli, or small round filters located in the kidney.


2)      Pyelonephritis

Ø Affects adults more than children, and is recognized as inflammation of the kidney and upper urinary tract.


3)      Hereditary nephritis

Ø A rare inherited condition.




causes and symptoms

Acute glomerulonephritis

Ø Usually develops a few weeks after a strep infection of the throat or skin.



Pyelonephritis

Ø Usually occurs suddenly, more common in adult women.
Ø The most common cause of this form of bacterial nephritis is the backward flow of infected urine from the bladder into the upper urinary tract.


Hereditary Nephritis

 Ø Present at birth. The rare disease presents in many different forms and can be responsible for up to 5% of end-stage renal disease in men.



diagnosis

Diagnosis of nephritis is based on
  • The patient's symptoms and medical history
  • Physical examination
  • Laboratory tests
  • Kidney function tests
  • Imaging studies such as ultrasound or x – rays to determine blockage and inflammation

Urinalysis can reveal the presence of:
  • Albumin and other proteins
  •  Red and white blood cells
  • Pus, blood, or bacteria in the urine 


treatment

Glomerulonephritis

Ø Drugs such as cortisone or cytotoxic drugs 
   (those that are destructive to certain cells or antigens).
Ø Diuretics may be prescribed to increase urination.
Ø Iron and vitamin supplements may be recommended if the patient becomes anemic.


Acute Pyelonephritis

Ø May require hospitalization for severe illness.
Ø Antibiotics will be prescribed, with the length of treatment based on the severity of the infection.
Ø Surgery is sometimes necessary.


Hereditary 

Ø Depends of the variety of the disease and severity at the time of treatment.




PROGNOSIS

Glomerulonephritis

Ø 90% of children recover without complications.


Pyelonephritis

Ø In the acute form offers a good prognosis if diagnosed and treated early.
Ø Follow-up urinalysis studies will determine if the patient remains bacteria-free.
Ø If the infection is not cured or continues to recured, it can lead to serious complications such as bacteremia , hypertension, chronic pyelonephritis and even permanent kidney damage.


Hereditary Nephritis

Ø If not detected or treated, it can lead to complications such as eye problems, deafness or kidney failure.





PREVENTION



Glomerulonephritis

Ø May lead by streptococcal infections but can be prevented by avoiding exposure to strep infection.


Pyelonephritis

Ø Can be avoid if those with a history of urinary tract infections take care to drink plenty of fluids, urinate frequently, and practice good hygiene.


Hereditary Nephritis

Ø Can not be prevented, but research to combat the disease continues.









PYELONEPHRITIS

PYELONEPHRITIS

DEFINITION



Kidney infection (pyelonephritis) is a specific type of urinary tract infection (UTI) that generally begins in your urethra or bladder and travels up into your kidneys.


pathways






PATHOPHYSIOLOGY






SIGNS and symptoms


Pyelonephritis may start with similar symptoms. However, once the infection has spread to the kidney, signs of more severe illness usually result:

·      Back pain or flank pain
·      Fever (usually present) and/or chills
·      Feeling sick (malaise)
·      Nausea  and vomiting
·      Confusion (especially in the elderly)

Pyelonephritis may cause noticeable changes in the urine, such as:
·      Blood in the urine (hematuria)
·      Cloudy or foul-smelling urine
·      Pain when urinating
·       Increased frequency or urgency of urination





CAUSES

·    Most cases of pyelonephritis start off as lower urinary tract infections, mainly cystitis and prostatitis.
·      Typically occurs when bacteria enter your urinary tract through the tube that carries urine from your body (urethra) and begin to multiply.
·      Bacteria from an infection elsewhere in your body also can spread through your bloodstream to your kidneys.
·      Bacteria found in stool (such as E. coli or klebsiella) are most common
·      When urine flow slows or stops, bacteria can more easily travel up the ureters. Some causes of urine obstruction include:
              -  Benign prostatic hypertrophy (BPH) 
- Abdominal or pelvic masses (as from cancer)
         - Stones in the bladder, ureters, or kidneys



classification







 






ACUTE PYELONEPHRITIS
                                                                       


DEFINITION
Acute pyelonephritis is a sudden and severe kidney infection. This condition causes the kidneys to swell, can permanently damage the kidneys, and can even be life threatening.




SIGN & SYMPTOM

Symptoms usually appear within one to two days after the infection begins. They may be different in children and the elderly than they are in adolescents and non-elderly adults. 











RISK FACTOR

·       Women more prone to kidney infections than men.
·       The elderly also have an increased risk of kidney infections.
·       People with suppressed immune systems, such as those with diabetes, AIDS  or cancer.
·       There are also other factors that can make you vulnerable to infection, such as:

©    using a catheter,
©    undergoing a cystoscopic examination,
©    having urinary tract surgery,
©    having an enlarged prostate,
©    certain medications,
©    nerve or spinal cord damage





DIAGNOSTIC TEST & IMAGING STUDIES


   In the outpatient setting, pyelonephritis is usually suggested by a patient’s history and physical examination and supported by urinalysis results.

Urinalysis can include the following:
·      Dipstick leukocyte esterase test (LET) - Helps to screen for pyuria
·      Nitrite production test (NPT) - To screen for bacteriuria
·      Examination for hematuria (gross and microscopic) and proteinuria

Imaging studies :
·      CT Scan  - To identify alterations in renal parenchymal perfusion; alterations in contrast excretion, perinephric fluid, and nonrenal disease, gas-forming infections, hemorrhage, inflammatory masses, and obstruction

·      Magnetic resonance imaging (MRI) – To detect renal infection or masses and urinary obstruction, as well as to evaluate renal vasculature

·      Ultrasonography - To screen for urinary obstruction in children admitted for febrile illnesses and to examine patients for renal abscesses, acute focal bacterial nephritis, and stones (in xanthogranulomatous pyelonephritis)

·      Scintigraphy - To detect focal renal abnormalities

·      CT and MR urography - Used in the evaluation of hematuria




TREATMENTS


·       Antibiotics are the first course of action against acute pyelonephritis.

·       If the type cannot be identified, a broad-spectrum antibiotic will be used.

·       Although treatment can cure the infection within two to three days, the medication must be taken for the entire prescription period, usually 10 to 14 days. Antibiotics options are:

©    Levofloxacin
©    Ciprofloxacin
©    Co-trimoxazole
©    Ampicillin

·       Recurrent kidney infections may result from an underlying medical problem. Surgery may be needed to remove any obstructions or correct any structural problems in the kidney that are causing the problem.



COMPLICATIONS
·      Chronic kidney disease
·      Recurring kidney infections
·      The infection spreading to areas around the kidneys
·      Acute kidney failure
·      Kidney abscess



 



CHRONIC PYELONEPHRITIS
                                                                       



DEFINITION

Chronic inflammation of the renal parenchyma and pelvis resulting from bacterial infection that often associated with a kidney stone or with narrowing of the urinary passageways.



ETIOLOGY

Chronic infection of the kidney resulting from vesiculourethral reflex or obstruction.



CLINICAL MANIFESTATION

Most patients with non – obstructive chronic pyelonephritis do not have specific symptomatology of the disease and present with the sequaele of hypertension or end – stage renal disease. Significant urologic symptoms usually occur in patients with obstruction. 





DIAGNOSTIC TEST


                  Radiographic – kidney with non – obstructive ( reflux ) chronic pyelonephritis are small with localized thinning of renal cortex and clubbing / dilatation of underlying calyces. Obstructive chronic pyelonephritis produces diffuse thinning of the renal cortex and uniform dilatation of calyces ( secondary to hydronephrosis ). 




TREATMENT

             Treatment of infection and correction of underlying defect are dialysis or renal transplantation in patients with end – stage renal disease.




COMPLICATIONS

·      Papillary necrosis
·       Acute renal failure
·       Chronic renal failure
·       Kidney stones
·       Hypertension in 30% of patients after more than 9-10 years of evolution.









NURSING DIAGNOSIS


Nursing Diagnosis: Acute pain related to disease process


Goal: Patient complain the pain is minimal

1)   Assess sign and symptoms of pain

R : Assessment allows for care plan modification , as needed


2)   Help patient into a comfortable position and use pillows to splint or support painful areas

R: To reduce muscle tension or spasm and to redistribute pressure on body parts


3)   Encourage patient to do diversional therapy such as listening      music, reading

R: To reduce their concern about the pain


4)   Provide patient with information to help increase pain tolerance for example reason for pain and length of time it will last

R: This educates patient and encourages compliance in trying alternative pain-relieves measures


5)   Administer analgesic medication when alternative methods of pain control inadequate

R: To reduce patient pain

6) Advise patient to urinate every 2-3 hours
R: To prevent the build up of urine in the urinary vesicles and cause patient pain

7) Palpation of the bladder every 4 hours
R: To determine the presence of bladder distention and if it happen patient will feel pain





   Nursing Diagnosis: Hyperthermia related to disease process

   Goal: Patient fever will be reduce

1)   Monitor and document temperature 2 hourly
R: For monitor patient health status

2)   Remove blankets / excessive clothing if necessary
R: To reduce heat in the body

3)   Encourage patient to drink plenty of water at least 8 glasses per day
R: Patient heat will be excrete through urine and fever will be reduce

4)   Perform tepid sponging if patient temperature 39o above
R: To reduce patient heat

5)   Promote good ventilation with switch on the air conditioner
R: Patient will feel more comfortable and heat will be reduce

6)   Administer antipyretic as prescribed
R: To reduce fever

7)   Administer antibiotic as prescribed

R: Patient fever because of infection, so give antibiotic can reduce patient fever






    Nursing Diagnosis : Knowledge Deficit related to Less Expose To The Disease


Goal: Patient knowledge will be increase and able to understand about their disease

1)   Asses the client’s understanding

R : We can know if patient understand about their diseases


2)   Expose client to other patients with same disease.

R : To reduce clients anxiety


3)   Always explain to client whenever providing some procedure to them

R : They do not know what us doing so must explain to reduce their anxiety


4)   Teach patient about sign and symptoms of pyelonephritis
R: If patient know the sign and symptoms ,patient can seek the doctor early

5)   Encourage family member to participate

R : Client will feel more comfortable if have family member